Graves病动物模型研究进展

摘要

In recent years,Graves disease( GD )can be induced in animals by several approaches:injecting cells stably expressing the TSH receptor( TSHK ); transient vaccination with TSHK-DNA in plasmid; transgenic models; passive transfer of monoclonal antibody; vaccination with TSHR A subunit in adenoviral vectors, among which the last one is the stable method with high incidence so far, and on that basis, there is also the tolerance model of BALB/C mice GD.%近年Graves病(GD)动物模型的研究方法主要有:用稳定表达促甲状腺激素受体(TSHR)的细胞免疫小鼠;短暂表达TSHR的质粒免疫小鼠;转基因动物模型;单克隆抗体被动免疫诱导;用表达TSHR-A亚单位的腺病毒免疫小鼠.其中,用TSHR-A亚单位的腺病毒免疫是目前诱导GD发病率高且稳定的方法.在此基础上,还有BALB/c小鼠GD免疫耐受模型的建立.