右美托咪啶的药理作用及在临床中的应用

摘要

Dexmedetomidine( DEX )is a highly specific, selective and potent ct2 adrenoreceptor agonist. The distribution half-life of DEX is 6 min and the elimination half-life of DEX is 2 h. The short distributionrnhalf-life of DEX makes it an ideal drug for intravenous titration. DEX has some effects of sedation, analgesia, hypnosis , inhibition of sympathetic nerve. Dexmedetomidine can significantly reduce the dose requirements for opioids and anaesthetic agents, and attenuate the stress response during tracheal intubation and tracheal extu-bation. It is a novel and promising anesthetic adjunct in the intensive care unit(ICU ).%右美托咪啶是高度特异选择性α2肾上腺素受体激动剂,它的分布半衰期为6 min,消除半衰期为2 h,较短的分布半衰期让它成为一种理想的静脉注射药.右美托咪啶具有镇静催眠、镇痛、抑制交感神经的作用,可使麻醉药用量明显减少,抑制气管插管、拔管时的应激反应,通常作为临床麻醉的辅助药和ICU镇静药.它是一种新型的、很有前途的麻醉辅助药.