Evaluation of Structure Effects on the Pharmacological Behavior of Radioiodinated Phenylpentadecanoic Acids

摘要

For studying the pharmacokinetic behaviour of fatty acids with different chemical structures four sup 123 I-labelled compounds, i.e., the ortho and para sup 123 I-isomers of 15-phenylpentadecanoic acid (IPPA) and 3-methyl-15-phenylpentadecanoic acid were prepared and the organ distribution determined in mice. The results show a significant decrease of the maximal heart uptake for the two ortho compounds. Further, the hypothesis of a blocked metabolism as an effect of the beta -methylation could not be confirmed. Both beta -methylated compounds show a biexponential elimination behavior from the heart. 5 refs., 2 figs. (ERA citation 11:017435)