There are few studies on the pharmacological properties of Valeriana prionophylla Standl. (VP), known as “Valeriana del monte”, and used in Mesoamerican folk medicine to treat sleep disorders. This study examines the pharmacological effects of the hydroalcoholic extract of the dry rhizome using the open field, rota rod, elevated plus-maze (EPM), forced swimming (FST), strychnine- and pentobarbital-induced sleeping time, PTZ-induced seizures, and the inhibitory avoidance tests. VP did not show any protective effect against PTZ-induced convulsions. In the EPM, exhibited an anxiolytic-like effect through the effective enhancement of the entries (38.5%) and time spent (44.7%) in the open arms, when compared with control group. Time spent and the numbers of entrances into the enclosed arms were decreased, similar to those effects observed with diazepam. In the FST, acute treatment with VP, produced a dose-dependent decrease in immobility time, similarly to imipramine. VP also produced a significant dose-dependent decrease in the latency of sleeping time, while producing an increase in total duration of sleep; influenced memory consolidation of the animals only at lower doses, unlike those that produced anti-depressant and anxiolytic effects. In summary, the results suggest that VP presents several psychopharmacological activities, including anxiolytic, antidepressant, and hypno-sedative effects.
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机译:缬草Standl的药理特性研究很少。 (VP),被称为“ Valeriana del monte”,用于中美洲民间医学中以治疗睡眠障碍。这项研究使用开阔视野,旋转棒,高迷宫(EPM),强迫游泳(FST),苯丙氨酸和戊巴比妥诱发的睡眠时间,PTZ诱发的癫痫发作,干燥根茎的水醇提取物的药理作用以及抑制性回避测试。 VP对PTZ引起的惊厥没有任何保护作用。在EPM中,与对照组相比,通过有效地增加张开双臂的入口(38.5%)和花费的时间(44.7%),表现出抗焦虑的作用。与用地西and观察到的效果相似,所花费的时间和进入封闭臂的次数减少了。在FST中,与imipramine相似,用VP进行急性治疗可导致剂量依赖性的固定时间减少。 VP还使睡眠时间的潜伏期显着剂量依赖性降低,同时增加了总睡眠时间。与产生抗抑郁和抗焦虑作用的动物不同,仅在较低剂量下才影响动物的记忆巩固。总之,结果表明VP表现出几种心理药理活性,包括抗焦虑,抗抑郁和催眠镇静作用。
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