糖尿病微血管障碍的发生机制及其与周围神经病变的关系

摘要

Microvascular dysfunction is an important pathogenesis of diabetic peripheral neuropa-thy( DPN). Changes of microvascular structures and functions, such as microvascular basement membrane thickening,increased permeability,vasodilation dysfunction and abnormal hemorheology,result in the formation and development of DPN through the mechanism of the destruction of the ionic balance, vascular permeability and blood-nerve barrier. Here is to make a review on the mechanism of changes of microvascular structures and functions and its relationship with DPN, which may provide some references for the prevention and treatment of DPN in clinical.%微血管障碍是糖尿病周围神经病变(DPN)的重要发病机制之一.长期的高血糖可诱导微血管的基膜增厚、通透性增加、血管舒张功能障碍及血液流变学异常,而微血管的这些变化通过破坏离子平衡、血管通透性及血-神经屏障等机制进而导致DPN的发生、发展.现就糖尿病微血管形态和功能变化的发生机制及其与DPN的关系予以综述,为临床上DPN的预防和治疗提供依据.