吸烟对COPD患者肺功能、IL-8及TNF-α的影响

摘要

Obstructive To detect the lung function,the serum levels of TNF-α,IL-8 of chronic ob-structive pulmonary disease( COPD) patients with smoking and non-smoking. Methods Total of 50 cases of patients with COPD came to Tianjin baodi district people′s hospital During March to May 2012,and than di-vided into COPD smoking group and non-smoking group according to smoking, selected 26 healthy people who came to hospital as the control group. The serum levels of TNF-α,IL-8 were measured by enzyme linked immunosorbent assay ( ELISA) , at the same time test their lung function. Results The serum levels of TNF-α,IL-8 in COPD smoking group and non-smoking group were higher than that of healthy group, the TNF-α and IL-8 levels in smoking COPD group were significant higher than non-smoking COPD group( P<0. 05),and the level of FEV1% was significantly lower(P<0. 05). The levels of TNF-αand IL-8 in smok-ing COPD group were positively correlated with smoking index,and the level of FEV1% was significant nega-tively correlated with smoking index(r= -0. 516,P<0. 001)Conclusion The levels of TNF-a and IL-8 are raised by COPD and smoking, giving up smoking is the important measure for preventing and reducing the incidence of COPD. Reducing the level of inflammation factors is a new strategy to improve the level of COPD airway inflammation of the progress.%目的：通过测定慢性阻塞性肺疾病( COPD)吸烟与非吸烟患者及健康人群的肺功能以及TNF-α、IL-8水平,探讨吸烟对COPD患者肺功能、TNF-α、IL-8水平的影响。方法选择2012年3~5月来天津市宝坻区人民医院呼吸科门诊就诊的50例处于稳定期的COPD患者作为研究对象,根据是否吸烟分为COPD吸烟组和COPD非吸烟组,选取同期来医院进行健康体检的26健康人作为健康对照组。采用酶联免疫吸附法测定所有受试者血清TNF-α、IL-8的水平,同时检测受试者的肺功能。结果 COPD吸烟组及COPD非吸烟组中受试者IL-8、TNF-α的水平均显著高于健康对照组( P<0.05),而第一秒用力呼气量占用力肺活量百分率(FEV1%)则显著低于健康对照组(P<0.05)；COPD吸烟组血清IL-8、TNF-α水平较COPD非吸烟组显著增高(P<0.05),FEV1%显著降低(P<0.05)；COPD吸烟组受试者血清中IL-8、TNF-α水平与吸烟指数呈正相关(r=0.549,0.458,P<0.001),而FEV1%与吸烟指数呈明显负相关(r=-0.516,P<0.001)。结论吸烟可引起COPD患者血清IL-8、TNF-α水平升高,FEV1%降低。因此戒烟是预防和降低COPD的发病率的重要措施,降低炎性因子的水平是改善COPD气道炎症进展的新策略。