甲状腺毒症大鼠心肌重构与碱性成纤维细胞生长因子的关系

摘要

目的：探索甲状腺毒症大鼠心肌重构与心肌碱性成纤维细胞生长因子( bFGF)的关系。方法45只成年雄性SD大鼠完全随机法分为两组,①对照组：给予盐水5 mL/kg灌胃；②甲状腺毒症模型组：给予左旋甲状腺素钠0.5 mg/kg灌胃。每日1次,4周后处死大鼠,测定心肌bFGF、心/体质量比、心肌细胞直径及胶原容积。结果甲状腺毒症模型组心/体质量比[(335±21) vs (260±32)]、心肌细胞直径[(15.0±1.6)μm vs (11.7±1.5)μm]、心肌胶原容积[(8.9±0.7)% vs (3.0±1.1)%]、心肌bFGF[(18.3±1.4) vs (5.6±1.1)]较对照组显著增加,差异有统计学意义。结论心肌bFGF与甲状腺毒症心肌重构有关。%Objective To explore myocardium bFGF relating to myocardial remodeling of thyrotoxia rats. Method 45 adult male SD rats were divided into 2 groups with completely random method,and were given gastic lavaga everyday for 4 weeks,①control group,with 5 mL/kg normal saline;②thyotoxic model group,with 0. 5 mg/kg levothyrocine. Executed the rats 4 weeks later. Measure myocardium bFGF,the ratio of heart weight to body weight,transverse diameter and collagen volume of myocardial cells. Result In the thyrotoxic model,ratio of heart weight to body weight,myocardial cell diameter,myocardial collagen volume, and myocardium bFGF expression significantly increased than control group. Conclusion The myocardium bF-GF relates to myocardial remodeling of thyrotoxia.