1，25二羟维生素D3缺乏与衰老的研究进展

摘要

1，25二羟维生素D3[1，25（OH）2D3]是维生素D的活性形式，其不仅参与调节机体钙磷代谢，还对心血管系统、免疫系统、泌尿系统、神经系统等多系统的活动具有调节作用。研究显示维生素D的减少与多种老年性疾病密切相关，维生素D在控制和改善与衰老相关的疾病方面起到了积极的作用。其机制可能与1，25（OH）2D3可通过调控与细胞衰老和凋亡的相关基因、降低氧化应激、抑制肾素－血管紧张素系统以及减少端粒耗损等有关。%Abstratc :1,25-dihyroxyvitamin D3[1,25(OH)2D3] is the active form of vitamin D in human body, whose function is not only to regulate the metabolism of body′s calcium and phosphorus,but also to regulate the activity of cardiovascular system,immune system,urinary system,nervous system and so on .According to the research data,the reduction of vitamin D is closely related to a variety of age-related diseases,vitamin D plays a positive role in the aging process ,especially in controlling and improving the age-related diseases.The mechanism is associated with the function of 1,25(OH)2D3 in regulating cellar aging and apoptosis,lowering oxidative stress,inhibiting renin-angiotensin system and reducing telomere loss.