经皮冠状动脉介入术后炎症激活及中药注射液干预的研究进展

摘要

冠状动脉粥样硬化性心脏病（冠心病）在全球范围内已成为威胁人类健康的重大疾病。目前，经皮冠状动脉介入（ PCI）是治疗冠心病的最有效手段之一，但术后部分患者出现了不同程度的临床不良事件。研究表明，PCI操作可激活冠状动脉及全身炎症反应，且贯穿于心脏不良事件的发生、发展过程。抑制炎症激活可以作为控制PCI术后心脏不良事件的重要途径。丹红等中药注射液可能通过多向性效应抑制PCI术后炎症激活，故中药注射液可作为PCI围术期改善预后的有效干预措施。%Coronary heart disease ( CHD ) has become a primary threat to human health all over the world.Currently,percutaneous coronary intervention(PCI) is one of the most effective strategies for CHD therapy.However,the patients undergoing PCI may suffer some adverse clinical events.It is found that PCI can activate coronary artery and systemic inflammatory response which exists throughout the process of the adverse cardiac events.Hence,inflammation inhibition can be for adverse cardiac events after PCI .Danhong and other Chinese injections may inhibit inflammatory reaction in patients after PCI,therefore can be used as an effective intervention to improve prognosis of PCI.