Topical composition, use of metronidazole or its pharmacologically acceptable derivative, methods to relieve pain caused by conditions, to relieve pain following a surgical operation, to reduce inflammation following a surgical operation, to promote healing following a surgical operation, to reduce edema following a surgical operation, to reverse hardening and granulation of the tissue following a surgical operation, and to treat conditions of the colon, rectum, anorectum, and perianal region, and method for treating ulcers anorectal or perianal

摘要

"TOPIC COMPOSITION, USE OF METRONIDAZOLE OR ITS PHARMACOLOGICALLY ACCEPTABLE DERIVATIVE, METHODS TO RELIEVE PAIN CAUSED BY CONDITIONS, TO RELIEVE SURGICAL OPERATION, TO REDUCE A PURPOSE FOR A CURRENT INFRASTRUCTURE CURE FOLLOWING A SURGICAL OPERATION, TO REDUCE EDEMA FOLLOWING A SURGICAL OPERATION, TO REVERSE TISSUE HARDENING AND GRANULATION, AND TO TREAT THE CURRENT, PERIOR AND CURRENT CONDITION METHOD FOR TREATING ANORETAL OR PERIANAL ULCERS ". A topical composition comprises at least 5% by weight of metronidazole or a pharmacologically acceptable derivative thereof in a non-aqueous vehicle. The composition may be used in the treatment of conditions of the colon, rectum, anorectum and perianal region, in particular inflammatory bowel disease and perianal Crohn's disease. The composition also relieves pain and inflammation and promotes healing of the colon, rectum, anorectum and perianal region following surgical operations. An advantage of the composition is that topical administration of metronidazole results in a primary local effect and thus the side effects observed by systemic administration are avoided.