脑脊液检查在中枢神经系统感染性疾病鉴别中的应用

摘要

Objective To investigate the role of cerebrospinal fluid(CSF) examination in the diagnosis of infectious diseases of central nervous system.Methods Clinical data of 194 cases of meningitis,including 61 cases of purulent meningitis,66 cases of tuberculous meningitis,and 67 cases of viral meningitis,was ret-rospectively analyzed.All the patients received CSF examination when hospitalized,results of CSF examina-tion of the three groups were compared.Results Leukocyte counts of patients with purulent meningitis ,viral meningitis,and tuberculous meningitis were (14.1 ±4.0) ×109/L,(7.2 ±1.3) ×109/L,(6.1 ±2.1) × 109/L,There were statistically significant differences among the three groups(F=3.682,P<0.05).Concern-ing the levels of total protein,albumin,IgM,IgG,glucose,lactate dehydrogenase,lactic acid,adenosine deami-nase,and neuron specific enolase,there were statistically significant differences among the three groups ( P<0.05).Conclusions Application of CSF examination in patients with infectious diseases of central nervous system,and comprehensive analysis of their multi-index test results of CSF,has certain clinical value in identif-ying the extent of brain damage.%目的：探讨脑脊液检查在诊断中枢神经系统感染性疾病中的作用。方法回顾性分析194例脑膜炎患者的临床资料，其中化脓性脑膜炎61例、结核性脑膜炎66例、病毒性脑膜炎67例。患者均于入院时实施脑脊液检查，分析三组患者脑脊液检查结果并比较。结果化脓性脑膜炎、病毒性脑膜炎、结核性脑膜炎患者白细胞计数分别为（14.1±4.0）×109／L、（7.2±1.3）×109／L 和（6.1±2.1）×109／L。三组患者的白细胞计数比较，差异有统计学意义（F＝3.682，P＜0.05）。三组患者的总蛋白、白蛋白、IgG、IgM及葡萄糖、乳酸脱氢酶、乳酸、腺苷脱氨酶、神经元烯醇化酶水平的比较，差异均有统计学意义（均P＜0.05）。结论对中枢神经系统感染性患者进行脑脊液检查，综合分析脑脊液多指标检查结果，对患者脑组织损伤程度判断具有一定的临床价值。