胆汁酸对糖脂及能量代谢调节作用的研究进展

摘要

Synthesized from cholesterol in the liver,bile acids are the main organic compounds in bile. Previously,bile acids were considered to facilitate the absorption and digestion of lipid-soluble nutrients. Recent studies have shown that bile acids can also function as endocrine signaling molecules that activate multiple nuclear and membrane receptor-mediated signaling pathways,playing important roles in regulating bile acids,glucose and lipid hemostasis as well as energy balance.These bile acid-activated signaling path-ways have pointed toward a new direction for developing therapies of obesity , diabetes and other metabolic diseases.%胆汁酸由胆固醇在肝内合成，是胆汁的主要有机成分。以往对胆汁酸功能的认识主要是其在促进脂类营养物质的消化和吸收方面的作用。近年来研究发现，胆汁酸还是一种有效的内分泌代谢调节因子，能够激活多种核受体和膜受体介导的信号通路，在调节其自身代谢、糖脂代谢的稳态以及能量代谢方面发挥着重要作用。深入研究胆汁酸及其代谢调节通路可为肥胖、糖尿病等代谢性疾病的治疗提供新的方向。