SDF－1／CXCR4与炎性疾病的相关研究进展

摘要

CXC趋化因子受体（ CXCR ）4作为一种趋化因子受体与其配体基质细胞衍生因子1（SDF－1）在人体多种组织与细胞中均有广泛表达，且两者结合能促进未成熟的中性粒细胞滞留于骨髓中，同时还能够诱导多种炎性细胞募集至炎症部位。 SDF－1／CXCR4轴参与多种炎症过程和疾病，包括WHIM（疣和感染及低丙种球蛋白血症伴先天性骨髓粒细胞缺乏）综合征、自身免疫性疾病、肺纤维化以及缺血损伤等，因此阻断CXCR4似乎成为了炎性疾病的一种新的治疗策略。%As a chemokine receptor,CXC chemokine receptor type 4 (CXCR4) and stromal cell derived factor 1 (SDF-1) are widely expressed in many tissues and cells of human body.Many studies have shown that binding of SDF-1 to CXCR4 retains immature neutrophils in the bone marrow and also participates in leukocyte recruitment into inflamed tissue .The SDF-1/CXCR4 axis is also involved in several inflammatory processes and diseases including WHIM ( warts, infections, hypogammaglobulinemia and myelokathexis ) syndrome,autoimmune disorders,pulmonary fibrosis,and ischemic injury.Based on these findings,blocking CXCR4 seems to be a therapeutic strategy for inflammatory diseases.