脏器损伤的组织往往会伴随强烈的炎症反应,而创伤后炎症过敏被认为是破坏宿主防御机制的重要不良事件.过氧化物酶体增殖物激活受体γ(PPARγ)是Ⅱ型核受体家族的成员之一,PPARγ及其配体已被认定为各种急性和慢性炎性病症中炎症的强力调节剂,可通过多种不同的信号转导途径下调下游编码促炎相关基因的转录,这与心血管疾病、肺损伤、脑和肠缺血/再灌注损伤等有密切联系.药理学上,PPARγ激动剂在多种脏器损伤动物模型中发挥强烈的抗炎特性,未来其可成为脏器损伤相关疾病的潜在治疗靶标.%Injured tissue of organs are usually accompanied by a strong inflammatory response,and post-traumatic inflammatory allergy has been considered to be a serious adverse event that destroys the host defense mechanism.Peroxisome proliferator-activated receptor γ(PPARγ)is a member of the type Ⅱ nuclear hormone receptors superfamily. PPARγ and its agonists have been identified as a strong regulator of acute and chronic inflammatory conditions,which pass through dif-ferent signal transduction pathways to regulate downstream encoding proinflammatory genes,and the cardiovascular disease, lung injury,brain and intestinal ischemia-reperfusion injury may be related to those processes.Pharmacologically,PPARγ agonists have markedly anti-inflammatory effect on animal models of multiple organ injuries,which can be a potential thera-peutic target for organ injury in the future.
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