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虎杖苷的药理作用研究进展

     

摘要

虎杖苷是虎杖等中药的有效成分,其是白藜芦醇与葡萄糖结合的产物,因而也称为白藜芦醇苷,其药理作用与白藜芦醇类似,可在体内相互转化,但虎杖苷具有更强的抗氧化作用和稳定性.虎杖苷具有调节离子通道以及蛋白激酶的作用,广泛应用于改善心肌损伤、改善血管内皮功能障、抑制血小板聚集、抗氧化、抗休克、抗肺动脉高压、降血脂以及抗血栓形成等,提示其具有重要的开发和临床应用价值.%Polydatin is an active ingredient of Polygonum cuspidatum and other traditional Chinese medicine ,which is the product of resveratrol and glucose binding , and is also known as resveratrol glycosides , with similar pharmacological effects of resveratrol ,with mutual in vivo transformation of each other ,but Polygonum cuspidatum glycosides have a stronger antioxidant and stability .Modern pharmacology has gradually explored the effects of ion channels , regulating protein kinase and other effects , widely used for improving myocardial injury , endothelial dysfunction , inhibiting platelet aggregation , antioxidant,anti-shock,anti-pulmonary hypertension,hypolipidemic and anti-thrombosis and other effects,suggesting that it has important developmental and clinical application value .

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