糖尿病肾脏疾病(DKD)是糖尿病的慢性并发症之一,严重危害人类健康,是导致糖尿病人群死亡的主要原因.虽然其发病机制目前未十分清楚,但遗传因素、糖脂代谢紊乱、肾脏血流动力学、氧化应激等促进了DKD的发生、发展.而炎性因子,尤其是巨噬细胞、趋化因子受体5、趋化因子配体2、白细胞介素(IL)1、基质金属肽酶9、IL-8及脂联素基因、转化生长因子β1等,在DKD的病理过程中发挥着重要作用.此外,基于这些炎性因子在DKD中的病理作用开发出了一些新型药物,其临床疗效值得肯定,同时也为DKD治疗开辟了新思路.%As one of the most serious chronic complications in diabetic patients ,the pathogenesis of diabetic kidney dis-ease( DKD) is not very clear , though it′s generally recognized that genetic factors , glycolipid metabolic disorders , renal hemodynamics and oxidative stress may play some roles in the onset and development of DKD .Inflammatory factors,espe-cially the chemokine receptor 5,chemokine ligand 2,interleukin( IL) 1,metal matrix peptides enzyme 9,IL-8,adiponectin gene,transforming growth factor-β1 etc.,may play an important role in the pathogenesis of DKD .Besides,some new drugs have been developed based on the pathological role of these inflammatory cytokines in DKD ,which showed positive clinical curative effect ,thus opening up a new window for the treatment of DKD .
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