IgA肾病机制的研究进展

摘要

IgA肾病(IgAN)是原发性肾小球肾炎最常见的类型,也是进展为终末期肾病的重要原因,其特征性表现为含有IgA1的免疫沉积物沉积于肾小球系膜区. IgAN的发病以及肾衰竭进程受遗传因素的影响.此外,外周血各类细胞释放的微粒、中性粒细胞释放的细胞外诱捕网、补体系统的变化等均会影响肾小球的功能,增加纤维蛋白与补体复合物在肾小球内的沉积,加速肾小球的损伤.了解IgAN的疾病机制对于IgAN的治疗有重要意义.%IgA nephropathy(IgAN) is the most common type of primary glomerulonephritis and is an important cause of progression to end-stage renal disease.The deposition of IgA1-containing immune deposits in the mesangial area is a charac-teristic manifestation of IgA nephropathy.The pathogenesis of IgAN and renal failure are related to genetic factors.Recent studies have found that microparticles released from peripheral blood cells ,extracellular traps released from neutrophil as well as complement system could influence the function of glomerular ,increase deposition of fibrin and complement comple-xes deposit in the glomeruli ,and accelerate the glomerular damage.Understanding the pathogenesis of IgA nephropathy is of great importance for the treatment of IgAN.