子宫内膜癌发病机制的研究进展

摘要

子宫内膜癌是妇科常见的三大恶性肿瘤之一,近年来其发病率不断升高,严重危害了妇女的健康.随着医学的发展,人们对子宫内膜癌发病机制的认识也不断深入.子宫内膜癌的分子发病涉及多种基因和信号通路的异常,如p53基因突变、微卫星不稳定性的增加、第10号染色体同源丢失性磷酸酶-张力蛋白基因突变、Notch信号通路等的异常,基因和信号通路的异常导致细胞增殖和凋亡失控,进而导致子宫内膜癌的发生、发展.目前关于宫内膜癌的分子发病机制尚不完全明确,仍需进一步探索.%Endometrial carcinoma is one of the three most common malignant tumors in gynecology.In recent years,the incidence of endometrial carcinoma is increasing,which seriously endangers the health of women.With the development of medicine,the understanding of endometrial carcinoma pathogenesis is also getting deeper.The molecular pathogenesis involves abnormalities of multiple genes and signaling pathways,such as the p53 gene mutation, microsatellite instability, phosphatase and tensin homolog deleted on chromosome ten mutation and Notch pathway abnormalities.Abnormal genes and signaling pathways lead to cell proliferation and apoptosis out of control,and then lead to endometrial carcinoma occurrence and development.At present,the molecular pathogenesis of endometrial carcinoma is still not completely clear,needing to be further explored.