血清同型半胱氨酸、血糖、糖化血红蛋白联合检测在糖尿病及其血管并发症中的意义

摘要

Objective:To investigate the serum homocysteine (Hcy) in diabetes and its vascularcomplications of the significance of detection of.Methods:patients without complications ofdiabetes and diabetes mellitus complicated with coronary heart disease (CHD), diabetes complicated with cerebral infarction (CVD), serum Hcy concentration of blood glucose andglycosylated hemoglobin detection, otherwise healthy control group of 30 at the same time to compare the detection. The concentration of serum Hcy by enzymatic cycling method,HbA1c by high performance liquid chromatography and by oxidase method and blood glucose,folic acid and VitB12 by electrochemical luminescence assay.Results:1 through the detection ofdiabetes without complications group and CHD group and CVD group, serum Hcy concentration of blood glucose, glycosylated hemoglobin concentrations were higher than those in the control group (P<0.05;P<0.01); 2.CHD group and CVD group with diabetes without complicationsgroup, ser um Hcy concentration increased significantly, through statistical analysis software,there is significant difference (P<0.05;P<0.01). Conclusions:1 the serum concentration of Hcy,concentration of blood glucose, glycosylated hemoglobin concentration and diabetes had close relationship with elevated serum Hcy; 2 diabetes patients are more susceptible to coronary heart disease, cerebral infarction and the concentration of vascular complications.%目的：探讨血清同型半胱氨酸（Hcy）检测在糖尿病及其血管并发症中的意义。方法：分别对糖尿病无并发症患者及糖尿病合并冠心病（CHD）、糖尿病合并脑梗死（CVD）进行血清Hcy浓度、血糖浓度和糖化血红蛋白检测，另有健康对照组30名同时进行比对检测。血清Hcy浓度采用循环酶法，HbA1c采用高效液相色谱法，血糖用氧化酶法，叶酸、VitB12用电化学发光法测定。结果：1.通过检测，糖尿病无并发症组及CHD组和CVD组血清Hcy浓度、血糖浓度、糖化血红蛋白浓度均高于对照组（P<0.05；P<0.01）；2.CHD组和CVD组与糖尿病无并发症组比较，血清Hcy浓度明显升高，通过统计学软件分析，有显著性差异（P<0.05；P<0.01）。结论：1.血清Hcy浓度、血糖浓度、糖化血红蛋白浓度与糖尿病发生关系密切；2.糖尿病患者血清Hcy浓度升高更易发生冠心病、脑梗死等血管并发症。