Objective To evaluate the effect of high dose cyclophosphamide plus methylprednisolone ambroxol on treatment of paraquat poisoning. Methods 77 patients with paraquat poisoning were divided into treatment group (n = 38) and the conventional group (n=39). The patients of the two groups were treated with gastric lavage, catharsis, adsorption, liver and kidney blood purification and retaining comprehensive treatment. Additionally, the treatment group was treated with a large dose of intravenous ambroxol 1. Og once daily for 2 weeks; plus methylprednisolone 1g. Central 0. 5g phosphorus amide intravenous use 3 days, changed to intravenous methylprednisolone 80mgQ12h cyclophosphamide 0. 2g Qd poisoning 14 days. The conventional group were treated with ambroxol 30mgbid, 0. 2g Qd intravenous methylprednisolone and cyclophosphamide 80mg Q12h to poisoning 14 days. Therapeutic effects were observed. Results 23 cases of the treatment group were cured and 15 cases died. 14 cases of the conventional group were cured and 25 cases died. Conclusion High dose cyclophosphamide plus methylprednisolone ambroxol treatment of paraquat poisoning can significantly reduce the mortality of paraquat poisoning.%目的 探讨大剂量氨溴索联合甲泼尼龙环磷酰胺治疗百草枯中毒的临床效果.方法 将收治的百草枯中毒患者77例为研究对象,分为治疗组(38例)与常规组(39例),两组病人入院后给予洗胃、导泻、吸附、血液净化及护肝肾等综合治疗,在此基础上,治疗组采用大剂量氨溴索1.0gQd静注,共2周；联合甲泼尼龙1g,环磷酰胺0.5g静注连用3天后改甲泼尼龙80mg1次/12h,环磷酰胺0.2g1次/日静注至第14天.常规组采用氨溴索30mg2次/日、甲泼尼龙80mg1次/12h及环磷酰胺0.2g1次/日静注至第14天,两组病人在中毒后15天改为口服强的松30mg1次/日至28天.分别于中毒后7天、14天、21天、28天和8周进行疗效评价,现察两组临床治疗效果.结果 8周后治疗组:治愈23例,治愈率为61％,常规组治愈14例,治愈率为36％,两组相比有显著性差异(P＜0.05);两组病人出院或死亡时动脉血氧分压比较有极显著性差异(P＜0.01).结论 大剂量氨溴索联合甲泼尼龙环磷酰胺治疗百草枯中毒可以明显降低百草枯中毒的病死率.
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