Objective To observe the efficacy of pleural cavity infusion of arsenic trioxide for malignant pleural effusion. Methods 36 patients with hydrothorax received catheterization in pleural cavity. After the pleural fluid had been adequately drained, all patiets received pleural cavity infusion of arsenic trioxide 20mg. Intrapleural infusion was given twice a week for four times. Results The overall response rate was 61% for 36 patients. Complete response was a-chieved in 7, partial response in 15, stable disease in 10 and progression disease in 4. The quality of life improved in 26 patients. Conclusion Pleural cavity infusion of arsenic trioxide is effective and safe in treatment of malignant pleural effusion. The side effects are tolerable.%目的 观察三氧化二砷胸腔内灌注治疗恶性胸腔积液的有效性和毒副反应.方法 36例恶性胸腔积液患者采用胸腔闭式引流尽可能排尽胸水后,给予胸腔内注入三氧化二砷20mg,每周腔内注射药物2次,连续2周.治疗结束后观察患者疗效及不良反应.结果 36例患者中,完全缓解7例,部分缓解15例,稳定10例,进展4例,总有效率61％.72％的患者生活质量得到改善.结论 腔内注入三氧化二砷治疗恶性胸腔积液疗效确切,不良反应小,安全性高,可在临床推广应用.
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