山莨菪碱逆转抗氯喹伯氏疟原虫抗药性的作用

摘要

As an auxiliary treatment, anisodamine, a calcium antagonist, was used to treat micerninfected by chloroquine resistant Plasmodium berghei. An obvious reverse effect of the drug onrnchloroquine resistance was observed. The growth of parasitemia in these mice was inhibited obviouslyrnby different doses of anisodamine and the mean survival time of these mice was longer than that of therncontrols (P<0. 05). It was found that the effect of dose at 20 mg/kg. d was higher than that of dose at rn5 mg/kg. d or 40 mg/kg. d and the difference was very significant (P<0. 005). It is considered thatrnanisodamine can reverse chloroquine resistant of Plasmodium berghei and has an optimum reversal dose.%用钙拮抗剂山莨菪碱对感染抗氯喹伯氏疟原虫小鼠进行辅助治疗，高、中、低三个剂量均rn可明显抑制原虫生长，使小鼠存活时间延长，但剂量为5mg/kg·d或40mg/kg·d时辅助治疗作用明显低rnrn于剂量为20mg/kg·d时(此剂量时实验组d4的平均原虫率为46．41‰，对照组67．76‰，rnrn rnrn0．005；实验组小鼠死亡时间几何均数为13．64±0．99d，对照组为rnrn 山rnrn莨菪碱逆转伯氏疟原虫氯喹抗药性的作用存在一个最适剂量。