高脂血症性急性胰腺炎超敏C反应蛋白检测的临床意义

摘要

Objective To explore the clinical diagnosis and treatment significance of the detection of hypersensitivity C reactive protein (hs-CRP) in the patients with hyperlipidemic acute pancreatitis (HLAP).Methods A total of 48 patients with HLAP constituted a HLAP group and 63 ones without HLAP a NHLAP group.The levels of blood hs-CRP,blood fat and amylase (AMY) and acute physiological and chronic health scores (APACHE Ⅱ scores) upon admission and the changes in RP within one week since the treatment between the two groups were compared.Results The blood hs-CRP,TG,TC and APACHE Ⅱ scores in the HLAP group were higher than those in the NHLAP (P ＜ 0.05),while the blood AMY between the two groups showed no statistical difference (P ＞0.05).At the same time point within one week since the treatment,the blood hs-CRP levels in the HLAP group were higher than those in the NHLAP group (P ＜ 0.05);and the hs-CRP in the two groups increased initially and decreased later.The peak value of hs-CRP occurred on the fourth day in the HLAP group and on the third day in the NHLAP group.Conclusion The condition of the patients with AP complicated with hyperlipemia is relatively serious.The monitoring of blood hs-CRP has important instructional significance in the evaluation of the severity and progress of the condition.%目的 探讨检测超敏C反应蛋白(hs-CRP)对高脂血症性急性胰腺炎(HLAP)的临床诊疗意义.方法 将48例高脂血症急性胰腺炎(HLAP)患者设为HLAP组,63例非高脂血症急性胰腺炎患者设为NHLAP组,比较两组入院时血hs-CRP、血脂、淀粉酶(AMY)水平及急性生理与慢性健康评分(APACHEⅡ评分),并比较两组治疗1 w内RP的变化.结果 HLAP组入院时的血hs-CRP、TG、TC及APACHEⅡ评分均高于NHALP组(P＜0.05),而两组血AMY无统计学差异(P＞0.05).在治疗的1 w内同一时间点,HLAP组的血hs-CRP水平均高于NHLP组(P＜0.05),且两组hs-CRP均呈现先升高再降低的趋势,HLAP组hs-CRP峰值出现在第4d,NHLAP hs-CRP峰值出现在第3d.结论 在急性胰腺炎患者中,合并高脂血症者的病情相对较重,血hs-CRP的监测对病情严重程度及病情进展的评估有重要指导价值.