利奈唑胺多药联合对患者血小板影响回顾性分析

摘要

Objective:The effect of linezolid combined with other antibiotics on the prognosis and the platelets was retrospetively analysed.Methods: The main screen standard was the start and stop time points of linezolid therapy, 82 patients who used linezolid for more than 7 days were involved in this study.Patients were divided into 4 groups: A = linezolid; B = linezolid + antibacterial agents; C = linezolid + antibacterial agents + antifungal antibiotic; D = linezolid + antifungal antibiotic.Statistics of the number of platelet were performed.Results:There were no significant difference in group B and C for the time of therapy( P ＞0.05 ).However, the baseline of platelet counts between group B and C was significantly different( P ＜ 0.05 ), and the platelet counts had a significant difference at different time points ( P ＜ 0.05 ).Conclusion: Combined use of linezolid with other antibiotics could decrease the platelet counts, but the effect was not significant.%目的:回顾性分析利奈唑胺与其他抗感染药物联合抗感染治疗期间,多药应用对患者血小板的影响.方法:以利奈唑胺应用起点及终点时间为主要筛选标准,筛选应用利奈唑胺时间＞7 d的患者共82例,分为4组:A=利奈唑胺;B=利奈唑胺+抗细菌药;C=利奈唑胺+抗细菌药+抗真菌药;D=利奈唑胺+抗真菌药.对各组血小板行统计分析,观察利奈唑胺对各组的影响.结果:用药时间对B组与C组血小板计数值的影响无显著性差异,但B组与C组应用利奈唑胺前血小板的计数值存在基线差异(P＜0.05),其后各时间点血小板计数值也存在统计学差异(P＜0.05),但各组血小板计数均在正常值范围.结论:在利奈唑胺多药应用过程中血小板计数虽有所降低,但该影响较小.