结肠直肠癌中FOXO4的表达与临床病理关系

摘要

Objective: To in vestigate the expression and clinical significance of forkhead transcription factor O4 (FOXO4) in colorectal cancer tissues. Methods:Immunohistochemical staining was used to detect the FOXO4 expression in 80 cases of colorectal cancer and adjacent normal tissue, and to analyze the relationship with clinical pathology parameters. Results:The positive expression rate of FOXO4 in colorectal cancer tissues was 54.9%(56/102), which was significantly lower than that in normal tissues adjacent to cancer89.2%(91/102) (P<0.05).Statistical analysis showed that for the FOXO4 expression there was no significant difference in the patients’age,gender, tumor size and invasion depth (P>0.05);howerver, there wre significant differences of expression in tumor differentiation,TNM stage and lymph node metastasis(P<0.05). Conclusion:FOXO4 transcription factor may be a negative regulator of cell proliferation, and is also a kind of cell apoptosis promoting factor. FOXO4 may function as a tumor suppressor in tumorigenesis, development, differentiation and metastasis.%目的：研究叉头样转录因子O4（FOXO4）在结肠直肠癌患者组织中的表达情况，并探讨FOXO4转录因子与结肠直肠癌发病间联系及临床意义。方法：选取结肠直肠癌102例患者手术切除肿瘤及其癌旁正常组织，应用免疫组织化学染色法检测FOXO4表达情况，并进一步分析其与患者临床病理参数的关系。结果：在CRC102例肿瘤组织中FOXO4阳性56例（54.9%），显著低于FOXO4在癌旁组织中的表达91例（89.2%），两者比较差异有统计学意义（χ2=27.335，P<0.05）。肿瘤组织中FOXO4表达水平在患者年龄、性别，肿瘤大小和浸润深度间差异无统计学意义（P>0.05）；但在肿瘤分化程度、TNM分期和淋巴结转移之间差异有统计学意义（P<0.05）。结论：FOXO4转录因子可能既是一种细胞增殖的负性调节因子，亦是一种细胞凋亡促进因子，参与肿瘤的发生、分化及转移，发挥肿瘤抑制因子的作用。