精神分裂症患者急性期与慢性期事件相关电位 P300对照研究

摘要

Objective:To investigate the difference and relation of the event related potential P300 for schizophrenic patients between the acute phase and the chronic phase. Methods: By using ERP instruments of Brain Products Company (Germany), the P300 was recorded and compared in 28 schizophrenic patients in the acute phase and 30 in the chronic phase. Moreover, the P300 was also measured at 6-months and 18-month follow-up after Risperidone treatment for the patients in the acute phase. Results: ( 1 ) Compared with the schizophrenic patients in the chronic phase, N1, N2, and P2 latencies delayed, and N2, P2, and P3 amplitudes decreased in the patients with acute schizophrenia (P<0. 05). (2) The follow-up of the acute schizophrenics showed that the P3 and P2 amplitudes of P300 increased along with the gradual ease of the mental symptoms of the patients in the acute phase, and the differ-ence was statistically significant before and after the treatment (P<0. 05). Conclusions: There are cognitive deficits in the patients with acute and chronic schizophrenia. The improvement of latency and amplitude of event-related potential P300 can be used as an e-valuation index for the improvement of cognitive function of the schizophrenics.%目的：：探讨精神分裂症患者急性期与慢性期事件相关电位P300的差别与联系。方法：应用德国Brain Products公司生产的ERP仪器,采集并比较28例急性期精神分裂症患者和30例精神分裂症慢性期患者的电位P300,并随访了精神分裂症急性期治疗6月、18月时电位P300。结果：①与精神分裂症慢性期比较,急性期精神分裂症患者的N1、N2和P2潜伏期延迟,N2、P2和P3波幅降低(P<0.05)；②对急性期精神分裂症患者的随访提示：随着精神分裂症急性期患者精神症状逐渐缓解,电位P300波幅P2及P3升高,治疗前后对比差异有统计学意义(P<0.05)。结论：精神分裂症急性期与慢性期患者存在认知功能缺陷。事件相关电位P300的潜伏期与波幅改善可以作为精神分裂症患者认知功能好转的一个评价指标。