精神分裂症患者事件相关电位P300的对照研究

摘要

目的:探讨精神分裂症患者听觉诱发电位P300的特征及病程对P300的影响. 方法:对68例精神分裂症患者(研究组)和30名正常对照(正常对照组)进行事件相关电位P300的检测,并分析比较不同病程对P300的影响. 结果:研究组Fz、Cz、FC1的P300潜伏期较对照组明显延迟(t分别=2.67,3.48,3.36;P均＜0.01)；Fz、Cz、FC1、FC2的波幅较对照组显著降低(t分别=5.97,2.54,4.57,3.80;P均＜0.01).对研究组中病程＜6个月组和病程＞5年组的患者比较发现,病程＞5年组的患者Fz、Cz潜伏期延迟(=9.23,7.63;P均＜0.01),波幅降低(t=11.97,6.66；P均＜0.01). 结论:精神分裂症患者认知功能受损,病程越长,受损越重.%Objective: To explore the characteristics auditory evoked potentials of schizophrenia patients and the effect of illness duration on P300. Method ;68 cases of schizophrenia patients and 30 cases of normal control group were measured events related potential P300, and the difference of disease progression was compared. Results:The research group had significantly longer latency at Fz,Cz,FCl (t = 2. 67,3.48,3. 36;all P<0.01) and lower amplitude at Fz,Cz,FCl and FC2( t = 5. 97,2. 54,4. 57,3. 80; all P<0. 01). Patients were divided into two groups by illness duration. The latency at Fz, Cz of 5 year illness duration of schizophrenia patients was significantly longer(t =9. 23 ,7. 63 ;all P <0. 01). Amplitudes were significantly lower(t = 11. 97, 6. 66;all P < 0. 01) . Conclusion: Patients with schizophrenia have cognitive function impairment. The longer the illness duration is,the more congnitive impairment is presented in patients with schizophrenia.