Objective To study the effects of combined leflunomide and cozaar therapy on IgA nephropathy. Methods Forty patients with IgA nephropathy diagnosed by renal biopsy were randomly divided into two groups; cozaar (100 mg/d) treated group and le-flunomide(20mg/d) plus cozaar treated group. The changes in proteinuria and serum creatinine were observed. Results After 1 month treatment by the two methods, the level of proteinuria decreased significantly [(0.92+0.53) vs (1.28+1.99) ] (P <0.05) in all. After 3 and. 6 months of treatment ? the level of proteinuria in combined, leflunomide End cozaar therapy group was lower than that in cozaar therapy group(P < 0. 05). Conclusions Combined leflunomide and cozaar therapy reduces 24 h urine proteinuria and protects renal function in patients with IgA nephropathy.%目的 探讨来氟米特联合科素亚治疗IgA肾病的疗效.方法 40例IgA肾病患者按照就诊时间顺序分为单纯科素亚治疗组(科素亚组)及来氟米特联合科素亚治疗组(联合组).分析两组治疗后 1、3、6个月24 h尿蛋白定量、血浆白蛋白、肾功能变化及不良反应.结果治疗3个月时,与科素亚组[(1.28±0.49) g/d]比较,联合组[(0.92±0.53) g/d]能明显降低24 h尿蛋白定量,两组治疗前后差异有统计学意义(P＜0.05).结论 来氟米特联合科素亚治疗IgA肾病,较单纯应用科素亚能减少蛋白尿,延缓肾功能进展.
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