可溶性血管细胞黏附分子1、妊娠血浆相关蛋白-A和白细胞介素6在妊娠高血压综合征中的作用

摘要

Objective To investigate the roles of soluble vascular cell adhesion molecule-l( sVCAM-1) , pregnancy associated plasmaprotein A(PAPP-A) and interleukin-6(IL-6) in pregnancy-induced hypertension.Methods Ninety-two pregnant woman diag-nosed as having pregnancy-induced hypertension were recruited and divided into gestational hypertension group (50 cases), preeclamp-sia group(30 cases)and eclampsia group(12 cases).Eighty healthy pregnant women were set as controls .sVCAM-1、PAPP-A were measured by chemiluminescence and IL-6 was measured by radioimmunoassay .Results The levels of sVCAM-1, PAPP-A and IL-6 in preeclampsia group and eclampsia group were significantly higher than those in control group (P<0.01).The levels of sVCAM-1 and PAPP-A had significant correlation in groups of preeclampsia and eclampsia (r=0.85, P<0.05), and the levels of IL-6 and sVCAM-1 had positive correlation in groups of preeclampsia and eclampsia (r=0.64, P<0.05).Conclusions SVCAM 1, PAPP-A and IL-6 have obvious ralationship with gestational hypertension .They can be applied in the clinical generalization , increase the rate of early diagnosis and treatment of eclampsia and reduce maternal and perinatal mortality .%目的：探讨可溶性血管黏附分子1（soluble vascular cell adhesion molecule-l，sVCAM-1）、妊娠血浆相关蛋白-A （pregnancy associated plasmaprotein A ，PAPP-A）和白细胞介素6（interleukin-6，IL-6）在妊娠高血压综合征（妊高征）发病中的作用。方法选取92例妊娠期高血压疾病孕妇（其中妊娠期高血压50例，子痫前期30例，子痫12例）和80例健康孕妇为对照组，检测其sVCAM-1、PAPP-A和IL-6水平。结果子痫前期、子痫患者血清sVCAM-1、PAPP-A和IL-6水平显著高于对照组（P＜0．01），子痫前期、子痫患者sVCAM-1和PAPP-A有显著正相关性（r＝0．85， P＜0．05）， IL-6和sVCAM-1呈正相关（r＝0．64， P＜0．05）。结论 sVCAM-1、PAPP-A和IL-6与妊娠期高血压疾病发作进展存在明显关联性，可推广性应用于实际临床工作，提高子痫早期诊疗率，降低孕产妇及围生儿病死率。