甲状腺功能减退与亚临床甲减症患者氧化应激指标变化分析

摘要

目的：探讨甲减和亚临床甲减患者氧化应激指标的变化.方法：测定46例甲减患者和44例亚临床甲减患者的丙二醛(MDA)水平、超氧化物歧化酶(SOD)活力、氧化型低密度脂蛋白(ox-LDL)含量等氧化应激指标的变化,并与44例正常健康体检者进行比较.结果：与对照组相比较,甲减和亚临床甲减患者SOD活性显著降低(P<0.01,P<0.05),MDA和ox-LDL水平显著升高(P<0.05,P<0.01).结论：MDA、SOD和ox-LDL等氧化应激指标,在甲减和亚临床甲减患者血清中有显著变化,这对临床上研究和诊断甲减和亚临床甲减具有重要的指导意义.%　　Objective:To investigate the changes of oxidative stress in patients with hypothyroidism and subclinical hypothyroidism. Method:Determination of 46 cases of patients with hypothyroidism and 44 patients with subclinical hypothyroidism in patients with MDA,SOD,ox-LDL,and 44 cases of normal healthy individuals for comparison.Result:Compared with the control group,SOD activity in patients with hypothyroidism and subclinical hypothyroidism was significantly decreased (P<0.01,P<0.05),MDA and ox-LDL were significantly increased (P<0.05,P<0.01). Conclusion:MDA,SOD,and ox-LDL oxidative stress parameters have significant changes in the serum of patients with hypothyroidism and subclinical hypothyroidism,which has important guiding significance for clinical research and diagnosis of hypothyroidism and subclinical hypothyroidism.