缺血后适应在降低急性心肌缺血狗再灌注损伤中的效果观察*

摘要

Objective:To observe and study the effect of ischemic postconditioning in decreasing the reperfusion injury of dogs with acute myocardial ischemia. Method:20 healthy hybrid dogs were selected as research object,and they were made as model of acute myocardial ischemia,then they were randomly divided into control group(direct restoration of blood flow)and observation group(ischemic postconditioning)with 10 cases in each group,and the serum myocardial enzymes,cTnI,BNP,MDA and left ventricular function of two groups at 40 min and 12 h after blocking blood flow were detected and compared. Result:The serum myocardial enzymes,cTnI,BNP,MDA and left ventricular function of two groups at 40 min after blocking blood flow had no significant differences,while the serum enzymes,cTnI,BNP,MDA of observation group at 12 h after blocking blood flow were all lower than those of the control group,left ventricular function indexes were all better than those of the control group,there were all significant differences (P<0.05). Conclusion:The effect of ischemic postconditioning in decreasing the reperfusion injury of dogs with acute myocardial ischemia is better, and it can effectively improve the cardiac status.%目的：观察研究缺血后适应在降低急性心肌缺血狗再灌注损伤中的效果。方法：选取20只健康杂种狗为研究对象，将其均制为急性心肌缺血模型，然后将其随机分为对照组（直接恢复血流）和观察组（缺血后适应），每组各10只，将两组分别于阻断血流40 min和12 h进行血清心肌酶、cTnI、BNP、MDA及心功能指标检测及比较。结果：两组阻断血流40 min时的血清心肌酶、cTnI、BNP、MDA及左心室功能指标差异均无统计学意义（P>0.05），而12 h时观察组的血清心肌酶、cTnI、BNP、MDA均低于对照组，左心室功能指标均优于对照组，比较差异均有统计学意义（P<0.05）。结论：缺血后适应在降低急性心肌缺血狗再灌注损伤中的效果较佳，可有效改善心功能状态。