藏药前列宁胶囊质量标准的研究

摘要

目的：研究并提高藏药前列宁胶囊的质量标准。方法：采用薄层色谱法鉴别红花、诃子、菥蓂子、藏茜草；采用高效液相色谱法同时测定没食子酸和羟基红花黄色素 A。结果：薄层色谱显色清晰，阴性对照无干扰。没食子酸在33.76~337.6μg/ml 浓度范围内线性关系良好，r=0.9996，平均加样回收率为98.35%，RSD 为1.36%。羟基红花黄色素 A 在2.68~26.80μg/ml 浓度范围内线性关系良好，r=0.9998，平均加样回收率为99.03%，RSD 为0.72%。结论：该方法简便、可行、可靠，可用于控制前列宁胶囊的质量。%Objective:To study and upgrade the quality standard of Tibetan Medicine Qianliening Capsule.Method:TLC method was used to identify Flos Carthami,Terminalia Chebula,Semen Thlaspi and Radix et Rhizoma Rubiae;Hplc was used for the determination of Gallic acid and Hydroxy Safflor yellow A.Result:Flos Carthami,Terminalia Chebula,Semen Thlaspi and Radix et Rhizoma Rubiae could be identified by TLC without the interference of negative control.Gallic acid and Hydroxy Safflor yellow A could be determined at the same time.Gallic acid was linear in the concentration range of 33.76-337.6μg/mL,r=0.9996.The average recovery rate was 98.35%,RSD=1.36%;Hydroxy Safflor yellow A had a good linear in the concentration range of 2.68-26.80 μg/ml,r=0.9998.The average recovery rate was 99.03%,RSD=0.72%.Conclusion:The method is simple, feasible,reliable,and can be effectively used for the quality control of Qianliening Capsule.