维生素B6、654-2、碳酸氢钠减轻阿奇霉素胃肠道反应效果的比较

摘要

Objective:To compare the vitamin B6,654-2,sodium bicarbonate in the azithromycin reaction of gastrointestinal tract effect. Method:Selected 150 cases whose respiratory tracted infection randomly from pediatric.And they were divided into group A,group B and group C, each group had 50 cases.On the basic treatment using azithromycin,supplemented with vitamin B6,654-2,sodium bicarbonate,in order to reduce gastrointestinal reaction,then compared the overall situation of gastrointestinal adverse reaction and occurrence degree of three groups after treatment using drug.Result:In nausea,vomiting,diarrhea and abdominal pain several adverse symptoms,group A was significantly lower than the group B, with significant difference(P<0.05),the difference between group B and group C was not significant(P>0.05);the occurrence of the adverse reactions, group A was significantly lower(P<0.05)than the B group,between group B and group C were not significant(P>0.05).Overall,the group A of adverse reaction incidence and degree of occurrence were relatively lower,with significant difference(P<0.05).Conclusion:In the azithromycin in gastrointestinal tract reaction,the overall effect of vitamin B6 with 654-2 sodium bicarbonate and relatively better,more worthy of clinical application.%　　目的：比较分析维生素 B6、654-2、碳酸氢钠在减轻阿奇霉素胃肠道反应中的效果。方法：随机选取儿科呼吸道感染的150例患儿，分为 A 组、B 组和 C 组，每组各50例，在使用阿奇霉素的同时，分别加用维生素 B6、654-2、碳酸氢钠以减轻患儿胃肠道反应，比较用药后，三组胃肠道不良反应整体发生情况和发生程度。结果：在恶心、呕吐、腹泻及腹痛几种不良反应症状上，A 组较之 B 组发生率明显降低，差异有统计学意义（P<0.05），B 组和 C 组比较差异无统计学意义（P>0.05）；在不良反应发生程度上，A 组较之 B 组发生程度明显降低，差异有统计学意义（P<0.05），B 组和 C 组比较差异无统计学意义（P>0.05）。整体比较，A 组不良反应情况发生率和发生程度均相对更低，差异有统计学意义（P<0.05）。结论：在减轻阿奇霉素胃肠道反应中，维生素 B6较之654-2和碳酸氢钠整体效果相对更佳，更值得临床推广应用。