目的：分析胰腺实性-假乳头状瘤的病理和免疫学特征，以探讨鉴别诊断方法。方法：选取本院从2006年10月-2013年2月收治的胰腺实性-假乳头状瘤32例，对其病理特征及免疫学资料进行分析。结果：肉眼见3.1~14.7 cm直径的肿物，平均（7.1±3.2）cm。32例中，13例有完整包膜，3例有部分包膜，3例囊性，6例实性，7例囊实性，光镜下可见实性区、囊性区及假乳头区。免疫学资料显示，β-Catenin阳性率为93.75%，E-Cadherin均为阴性；细胞核阳性率为100%；胞质阳性率为81.25%；Vimentin均强阳性；NSE阳性率为90.63%；CD10阳性率为87.5%；CK18阳性率为96.88%；Syn阳性率为46.88%；ChrA31阴性率为96.88%。结论：胰腺实性-假乳头状瘤的诊断和鉴别诊断应根据临床、病理特征、免疫学检测综合分析。%Objective:To analyze the clinicopathological and immunohistochemical features of solid pseudopapillary tumors of the pancreas,to investigate the methods of differential diagnosis.Method:33 solid-pseudopapillary tumors of the pancreas were selected and analyzed from our hospital during October 2006 to February 2013.Result:The mean diameter(7.1±3.2)cm with the range of 3.1-14.7 cm included 13 cases with complete capsule, 3 cases with partly capsule,3 cases with cystic,6 cases with solid,7 cases with cyst-solidary.The main histology performance in light the microscope included solid area,cystic area and fake nipple area.Immunohistochemical showed the positive rate was 93.75%ofβ-Catenin,E-Cadherin was negative,the positive rate was 100%of the nucleus of a cell, 81.25%of cytoplasm,100%of Vimentin,90.63%of NSE,87.5%of CD10,96.88%of CK18,46.88%of Syn,3.12%of ChrA31.Conclusion:The diagnosis and differential diagnosis of solid-pseudopapillary tumor of the pancreas need the clinical symptoms,clinicopathological and immunohistochemical features.
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