毛细支气管炎患儿发展为哮喘的相关因素分析

摘要

Objective:To explore the related factors in children with bronchiolitis may develop asthma. Method:For children with bronchiolitis 108 cases were followed up for 3 years. Children with gender,maternal age at birth,father smoking,birth weight,while the incidence of drug and food allergies,family history,immune globulin,feeding patterns, inhaled corticosteroids,allergies,passive smoking,immune globulin,blood routine,trace elements and other indicators were used Logistic regression analysis. Result:Univariate analysis showed that sex,place of residence,father smoking status,age of the mother when the children were born,mode of delivery,birth weight,home decoration or not,the onset of the season,the number of hospital days during bronchiolitis,RSV infection,food allergy drugs history,passive smoking,family history of asthma and allergic rhinitis,atopy,recurrent respiratory tract infections,blood IgE,blood lead,zinc blood,serum iron,eosinophil count and after bronchiolitis into asthma. Multivariate Logistic regression analysis showed:gender(boys),age of the mother when the children were born,passive smoking,the onset of spring,RSV infection positive abnormal birth weight,drug or food allergies,family history of asthma,elevated serum IgE the children with bronchiolitis into a high risk of asthma in children. Conclusion:For children with bronchiolitis risk factors for the development of asthma,early active intervention to reduce morbidity.%目的：探讨毛细支气管炎患儿可能发展为哮喘的相关因素。方法：对108例毛细支气管炎患儿随访3年。对患儿性别、出生时母亲年龄、父亲吸烟、出生体重、发病时情况、药物及食物过敏史、家族史、免疫球蛋白、喂养方式、吸入激素、过敏体质、被动吸烟、免疫球蛋白、血常规、微量元素等指标进行Logistic回归分析。结果：单因素分析结果提示：性别、居住地、父亲吸烟与否、患儿出生时母亲年龄、分娩方式、出生体重、家庭装修与否、发病季节、毛细支气管炎期间住院天数、RSV感染、药物食物过敏史、被动吸烟、哮喘及过敏性鼻炎家族史、特应性体质、反复呼吸道感染、血IgE、血铅、血锌、血清铁、嗜酸细胞计数与毛细支气管炎后转化为哮喘有关。多因素非条件Logistic回归分析结果显示：性别（男孩）、患儿出生时母亲年龄、被动吸烟、春季发病、RSV感染阳性、出生体重异常、药物或食物过敏史、哮喘家族史、血IgE升高的毛细支气管炎患儿转化为儿童哮喘的危险性高。结论：对于毛细支气管炎患儿发展为哮喘的危险因素，应及早积极干预，降低发病率。