改良电痉挛法联合帕罗西汀治疗首发抑郁症的疗效及不良反应

摘要

Objective:To explore the clinical efficacy and incidence of adverse reaction of modified electroconvulsive combined with paroxetine in the treatment of first-episode depressive patients. Method:85 cases of first-episode depressive from February 2009 to December 2012 in our hospital as observation objects,the cases were divided into 45 cases in study group and 40 cases in control group according to random number table method,the study group was treated with modified electroconvulsive combined paroxetine comprehensive treatment,the control group only with paroxetine drug treatment. The clinical treatment,Hamilton Depression Scale(HAMD)score after 8 weeks and adverse reactions of two groups were observed. Result:After 4 week, 8 week,HAMD score in the study group was significantly lower than the control group,the difference between two groups was significant(P<0.05);the total effective rate in the study group after 8 weeks was 97.78%,the control group was 85.00%,the difference had significant(P<0.05);the adverse reaction incidence in the study group was 22.22%after treatment,and higher than that in the control group(20.00%),but there was no significant difference(P>0.05). Conclusion:The clinical effect of modified electroconvulsive combined paroxetine in the treatment of first episode depression is stable,and high safety.%目的：探讨改良电痉挛法联合帕罗西汀治疗首发抑郁症患者的临床疗效及不良反应发生率。方法：选取2009年2月-2012年12月本院收治的85例首发抑郁症患者作为观察对象，按随机数字表法分为研究组45例和对照组40例。研究组患者采用改良电痉挛法联合帕罗西汀综合治疗，对照组患者仅用帕罗西汀药物治疗。观察两组治疗8周后的临床疗效、汉密尔顿抑郁量表（HAMD）评分及不良反应。结果：研究组治疗后4周、8周HAMD评分低于对照组，两组比较差异有统计学意义（P<0.05）；研究组治疗8周后总有效率为97.78%，对照组为85.00%，差异有统计学意义（P<0.05）；研究组治疗后不良反应发生率为22.22%，略高于对照组的20.00%，但差异无统计学意义（P>0.05）。结论：改良电痉挛法联合帕罗西汀治疗首发抑郁症临床效果稳定，安全性高。