阻塞性睡眠呼吸暂停低通气综合征患者血清IL-6、IL-17水平变化及临床意义

摘要

Objective:To discuss the change and clinical significance of serum IL-6 and IL-17 levels in patients with obstructive sleep apnea-hypopnea syndromes (OSAHS).Method:102 patients with OSAHS who were diagnosed by polysomnagraphy (PSG) and 98 cases of healthy as control group were selected from May 2013 to Octomber 2014, the general clinical data, apnea-hypopnea index (AHI) and lowest arterial oxygen saturation (LSaO2) of them were retrospectively analyzed.The serum IL-6 and IL-17 levels were determined by enzyme-linked immunosorbent assay (ELISA), and its correlation with OSAHS were analyzed.Result:Compared with the control group,the serum IL-6 and IL-17 levels of OSAHS patients increased and increased with the severity of OSAHS,there was statistically significant difference between them(P<0.05).The serum IL-6 and IL-17 levels of OSAHS patients presented positively correlated with AHI(r=0.868,P<0.05;r=0.896,P<0.05),but negatively correlated with LSaO2(r=-0.769,P<0.05;r=-0.703, P<0.05).Conclusion:The levels of serum inflammatory cytokines IL-6 and IL-17 are higher in OSAHS group,suggests its participation in OSAHS disease process,and it can be used as biological index of the severity of OSAHS.%目的:探讨阻塞性睡眠呼吸暂停低通气综合征(Obstructive sleep apnea-hypopnea syndromes, OSAHS)患者血清炎性因子白细胞介素-6(Interleukin,IL-6)、白细胞介素-17(Interleukin,IL-17)水平变化及临床意义.方法:回顾性分析2013年5月-2014年10月间本院呼吸科门诊及住院部经多导睡眠图(Polysomnagraphy,PSG)监测确诊的102例OSAHS患者,及同期本院体检中心98例健康体检者的一般临床资料、睡眠呼吸暂停低通气指数(Apnea-hypopnea index,AHI)、最低血氧饱和度(Lowest arterial oxygen saturation,LSaO2).采集静脉血,分离血清,酶联免疫吸附法(Enzyme-linked immunosorbent assay,ELISA)检测患者血清IL-6、IL-17水平并分析其与OSAHS的相关性.结果:与健康对照组比较,OSAHS组的血清IL-6、IL-17水平均升高,差异有统计学意义(P<0.05),且血清IL-6、IL-17水平随OSAHS分布严重程度的升高而升高.OSAHS组的血清IL-6、IL-17水平与AHI呈正相关(r=0.868,P<0.05;r=0.896,P<0.05),而与LSaO2呈负相关(r=-0.769,P<0.05;r=-0.703,P<0.05).结论:血清炎性因子IL-6、IL-17水平在OSAHS组患者中升高,提示其参与OSAHS疾病进程,可以作为OSAHS严重程度的生物学指标.