10117例女性公务员宫颈高危型HPV感染与TCT相关性分析

摘要

目的:分析长沙市部分女性公务员宫颈高危型HPV感染与TCT相关性.方法:对2012年10-12月在长沙市妇幼保健院健康管理中心体检的10 117例女性公务员按照年龄进行分组,并采用PCR加膜杂交法进行HPV分型检测及TCT检测.结果:高危型HPV感染率为8.98%(909/10 117),检出比例占前3位的高危型HPV分别是HPV52型(31.46%)、58型(19.36%)及16型(16.17%),其中单一、双重及三重感染所占比例分别为83.06%、13.42%、3.52%;909例高危型HPV感染者中细胞学异常者76例(8.4%),其中高危型HPV16、33型出现细胞学HSIL病变的比例远高于其他分型.结论:HPV分型与TCT联合检测可以提高宫颈癌筛查有效性,对HPV16、33型感染的女性应重视宫颈癌筛查.%Objective:To analyze the correlation of cervical high risk human papilloma virus infection and thinprep cytologic test in part of female civil servants in Changsha.Method:10 117 female civil servants who were examined in the health management center of Changsha maternal and child health hospital from October 2012 to December 2012 were grouped according to their ages.HPV genotyping was tested by PCR and membrane hybridization.The examination of TCT was also given to the patients.Result:The infection rate of high risk HPV was 8.98%(909/10 117). Among all the high-risk HPV,the top 3 were HPV52(31.46%),HPV58(19.36%) and HPV16(16.17%).The rates of single infection,double infections and three infections were 83.06%,13.42% and 3.52% respectively.In the 909 cases of high-risk HPV infection,the number of cytological abnormalities was 76(8.4%).The HSIL in high-risk type HPV16 and HPV33 were higher than other types.Conclusion:The joint of HPV genotyping and TCT can improve the effectiveness of cervical cancer screening.Cervical cancer screening shall be paid attention in female who has been infected HPV16 and HPV33.