急性脑梗死患者血清胆红素、D-二聚体的动态监测及其临床意义

摘要

Objective:To discuss clinical significance of dynamic monitoring the serum bilirubin,D–dimer(DD) in patients with acute cerebral infarction(AMI).Method:78 patients with AMI were selected in our hospitals as AMI group,20 cases of health personn were selected from medical center for the same period as healthy group, serum bilirubin, DD level were detected by using enzyme-linked immunosorbent method ,and analyzed change of serum bilirubin, DD level of AMI patients in hospital, the acute phase and after treatment serum bilirubin, DD level.Pearson analysis method were used to analyze the relationship between them.Result:AMI group patients bilirubin,DD expression level were higher than healthy group,the difference was statistically significant(P<0.05).AMI patients in acute phase serum bilirubin,DD expression level were the highest,the expression level at hospitalization serum bilirubin,DD findings was the second,the expression level after treatment serum bilirubin,DD expression was the lowest(P<0.05).Pearson analysis results showed that the serum bilirubin level was positively correlated with DD level(r=0.689,P=0.689).Conclusion:AMI patients can cause and serum bilirubin,DD expression level change, and both are positively correlated,the dynamic monitoring the expression level of disease progression and the curative effect of patient evaluation have an important reference value.%目的：探讨急性脑梗死（acute cerebral infarction，AMI）患者血清中胆红素、D-二聚体（D–dimer， DD）的动态监测及其临床意义。方法：选取2012年3月-2014年6月本院确诊的AMI患者78例作为AMI组，同期选取体检中心健康人员20例作为健康组，采用酶联免疫吸附法检测所有受试者血清中胆红素、DD表达水平，统计分析AMI患者住院时、急性期和治疗后血清中胆红素、DD表达变化，应用Pearson分析法分析两者之间的关系。结果：AMI组患者血清中胆红素、DD表达水平明显高于健康组，差异有统计学意义（P<0.05）；AMI组患者在急性期血清中胆红素、DD表达水平最高，在住院时血清中胆红素、DD表达水平次之，治疗后血清中胆红素、DD水平最低，差异有统计学意义（P<0.05）；Pearson分析法结果显示，血清中胆红素水平与DD水平呈正相关（r=0.689，P=0.006）。结论：AMI患者发病时可引起血清中胆红素、DD表达水平发生改变，且两者呈正相关，动态监测其表达水平对评估患者病情进展和疗效具有重要的参考价值。