鸦胆子油鼻用pH敏感型原位凝胶的处方筛选

摘要

Objective:To screen the best prescription of java brucea fruit oil of nasal in situ gel pH-sensitive.Method:Carbomer 934,hydroxypropyl methyl cellulose SHE50,SHE15,SHK4M,SHK100M were used as matrix,twain-80, N-methyl pyrrolidone were used as solubilizer,through the experiment in situ gel preparation viscosity prescription screening, solution clarity were evaluated under condition of gel pH and concentration of gelation as optimization prescription.Result:In situ gel pH-sensitive viscosity increased with the increase of pH and substrate concentration,after joined artificial nose liquid formation strength of the gel.The optimization result was that best carbomer concentration of 0.5%,hydroxypropyl methyl cellulose SHE50 optimal concentration of 0.25%,twain-80 10.44 g and 2.18 g N-methyl pyrrolidone,it could make the 5 mL java brucea a fruit oil completely dissolved.Conclusion:Carbomer at 0.5%,0.5% hydroxypropyl methyl cellulose SHE50 gel matrix,twain-80 and N-methyl pyrrolidone as solubilizer,can be successful preparation of java brucea fruit oil pH-sensitive nasal in situ gel.%目的：筛选鸦胆子油鼻用pH敏感型原位凝胶的最佳处方，为鸦胆子油鼻用pH敏感型原位凝胶的制备提供基础。方法：以卡波姆934、羟丙基甲基纤维素SHE50、SHE15、SHK4M、SHK100M为基质，以吐温-80、N-甲基吡咯烷酮为增溶剂，通过黏度实验进行原位凝胶制剂的处方筛选，并在不同的pH、不同基质浓度的条件下，优化处方。结果：pH敏感型原位凝胶的黏度随着pH、基质浓度的增大而上升，加入人工鼻液后形成具有一定强度的凝胶。优选结果为卡波姆浓度最佳为0.5%，羟丙基甲基纤维素SHE50最佳浓度为0.25%，10.44 g吐温-80、2.18 g N-甲基吡咯烷酮，可使5 mL鸦胆子油完全溶解。结论：以0.5%卡波姆、0.25%羟丙基甲基纤维素SHE50为凝胶基质，以吐温-80，N-甲基吡咯烷酮为增溶剂，可成功制备鸦胆子油pH敏感型鼻用原位凝胶。