Preparation of a Thermosensitive Guanidine-Chitosan/Poloxamer in situ Gel for Intranasal Delivery System

摘要

A novel themosensitive in situ gel was prepared by using Poloxamer407 and poloxamer188 combined with membrane penetration enhancer Guanidine-Chitosan. Orthogonal experiment optimization was used to study of formulations conditions that suit to intranasal drug delivery. The optimal intranasal gel formulation has been further checked for viscosity behavior against temperature. The result showed that the optimal formulation was 18% P407 (w/w), 3% P188 (w/w), 2% GCS (w/w), which have prospective gelation temperature 29.5°C. Evaluation of Guanidine-chitosan influence in gelation temperature showed slight decrease the point of hydrogel system.