SLE患者血清IRF4与疾病活动性指数、抗SSA抗体的相关性分析

摘要

目的：探讨系统性红斑狼疮（systemic lupus erythematosus，SLE）患者血清干扰素调节因子（interferon regulatory factor，IRF4）与疾病活动性指数（disease activity index，DAI）、抗SSA抗体的关系。方法：选取本院2012年1月-2014年12月SLE患者60例作为观察组，健康体检者55例作为对照组，采用酶联免疫吸附试验（Enzyme-Linked Immuno Sorbent Assay，ELISA）法检测血清IRF4水平，Pearson相关性分析IRF4与DAI、抗SSA抗体的关系。结果：观察组血清干扰素调节因子水平明显高于对照组，DAI≥6分的系统性红斑狼疮患者血清干扰素调节因子水平明显高于DAI<6分的系统性红斑狼疮患者，抗SSA抗体阳性的的系统性红斑狼疮患者血清干扰素调节因子水平明显高于抗SSA抗体阴性的系统性红斑狼疮患者，比较差异均具有统计学意义（P<0.05）。经Pearson相关性分析发现，血清干扰素调节因子与DAI呈明显的正相关性（r=0.45，P<0.05），与抗SSA抗体呈明显的正相关（r=0.43，P<0.05）。结论：血清干扰素调节因子（IRF4）在系统性红斑狼疮患者中显著增高，其与疾病活动性指数、抗SSA抗体具有明显相关性，干扰素调节因子（IRF4）具有促进系统性红斑狼疮疾病的发生和发展。%Objective:To investigate the correlation analysis on serum interferon regulatory factor (IRF4) and disease activity index(DAI),anti SSA antibody in systemic lupus erythematosus (SLE).Method:60 systemic lupus erythematosus patients in our hospital from January 2012 to December 2014 were selected as the observation group,55 healthy cases were selected as the control group,the level of serum interferon regulatory factor was detected by Enzyme-Linked Immuno Sorbent Assay (ELISA) method,the relationship between serum interferon regulatory factor and disease activity index,anti SSA antibody was analyzed by the Pearson correlation.Result:The level of serum interferon regulatory factor of the observation group was significantly higher than that of the control group,serum interferon regulatory factor level of disease activity index≥6 points of systemic lupus erythematosus patients was higher than disease activity index<6 points of systemic lupus erythematosus patients, serum interferon regulatory factor level of anti SSA antibody positive in systemic lupus erythematosus patients was significantly higher than anti SSA antibody negative in systemic lupus erythematosus patients,there was statistically significant difference (P<0.05).The Pearson correlation showed that,there was no significant relationship between serum interferon regulatory factor and disease activity index (r=0.45,P<0.05),serum interferon regulatory factor had significant positive correlation with anti SSA antibody (r=0.43,P<0.05).Conclusion:The serum interferon regulatory factor of systemic lupus erythematosus is higher,it has obvious correlation with disease activity index and anti SSA antibody,interferon regulatory factor promote the occurrence and development of systemic lupus erythematosus.