预注布托啡诺对依托咪酯在全麻诱导时导致肌阵挛的影响

摘要

Objective:To investigate influence of pre-injection Butorphanol on myoclonus caused by Etomidate during induction of general anesthesia.Method:To be under general anesthesia for elective surgery were 180 cases, ASAⅠ or Ⅱ, male 85 cases, female 95 cases, aged 20 to 65 years old, weighing 42-59 kg, were randomly divided into butorphanol group (group B), Sufentanil group (S group) and control group (N group), 60 cases in each group. Group B received butorphanol 20 µg/kg (total not more than 2 mg); S group received sufentanil 0.2 µg/kg, N group given the same volume of saline, 1 min three groups of patients after intravenous injection of etomidate acetate 0.3 mg/kg, injection time 30 s and continued to observe for 2 min, spasm conditions was observed and the severity was assessed.Result:Of the three groups of patients during induction BP, HR difference was not statistically significant, all patients SpO2> 97%; compared with the N group, group B, S myoclonic patients significantly reduced the number of cases 1,2,3,muscle Array twin significantly lower incidence(P<0.05).Conclusion:Preinjection 20 µg/kg butorphanol can effectively reduce lead time etomidate induced myoclonus occur.%目的：探讨预注布托啡诺对预防依托咪酯导致肌阵挛的效果。方法：拟在全麻下择期手术患者180例，ASA Ⅰ或Ⅱ级，男85例，女95例，年龄20~65岁，体重42~59 kg，随机分为布托啡诺组（B组）、舒芬太尼组（S组）和对照组（N组），每组各60例。B组给予布托啡诺20µg/kg（总量不大于2 mg）；S组给予舒芬太尼0.2µg/kg、N组给予同容积的生理盐水，1 min后三组患者均静注依托咪酯0.3 mg/kg，注射时间30 s，并持续观察2 min，观察痉挛发生情况和评估严重程度。结果：诱导期间三组患者的BP、HR差异无统计学意义，所有患者SpO2>97%；与N组比较，B组、S组患者肌阵挛1、2、3级例数明显减少，肌阵挛发生率明显降低（P<0.05）。结论：预注20µg/kg布托啡诺可有效减少依托咪酯诱导时导致的肌阵挛发生。