PAX8、WT-1、HER2在不同转移方式的晚期卵巢上皮性癌中的差异表达

摘要

目的：探讨PAX8、WT-1、HER2在不同转移方式的晚期卵巢上皮性癌中的表达差异，为临床治疗提供一定的理论基础。方法：收集临床样本，按照转移方式分为淋巴结转移组1例、混合转移组14例和盆腹腔转移组5例。采用实时定量荧光PCR方法检测PAX8、WT-1、HER2在20例不同转移方式的晚期卵巢上皮性癌中的相对表达量。结果：PAX8、WT-1、HER2在20例患者中均有表达；混合转移组PAX8、WT-1、HER2基因表达高于盆腹腔转移组。结论：PAX8、WT-1、HER2基因的表达可能与肿瘤的转移方式有关，可能成为提示预后的基因指标并对临床有一定提示作用，但仍需扩大样本进一步验证。%Objective:To explore the differential expression of PAX8,WT-1 and HER2 in advanced epithelial ovarian cancer with different metastatic modes and provide some theoretical basis for clinical treatment. Method:The clinical samples were collected,they were divided into lymph node metastasis group of 1 case, mixed metastasis group of 14 cases and pelvic-abdominal metastasis group of 5 cases according to the metastasis ways.The relative expression of PAX8,WT-1 and HER2 in 20 patients with advanced epithelial ovarian cancer were detected by real-time quantitative fluorescent PCR method.Result:20 cases all had expressed PAX8,WT-1 and HER2.The expression of PAX8,WT-1 and HER2 in mixed metastasis group was higher than that of pelvic-abdominal metastasis group.Conclusion:The expression of PAX8,WT-1 and HER2 may be associated with the metastasis way of tumor,and probably become the genetic indicators for clinical work,but it is necessary to expand the sample for further validation.