目的 探讨定量检测可手术的非小细胞肺癌患者外周血cfDNA总浓度及长片段DNA浓度的临床价值.方法 选择2017年1月～12月承德市中心医院胸外科60例可手术的非小细胞肺癌患者为实验组, 分别于手术前1 d、手术后7 d、手术后20 d采集外周静脉血液标本, 同期于承德市中心医院体检中心选择60例健康体检者为对照组, 采集外周静脉血液标本, 定量检测两组标本血液中cfDNA总浓度及长片段DNA浓度, 进行统计学分析.结果 实验组患者手术前1 d外周静脉血中cfDNA总浓度较对照组升高, 差异具有统计学意义 (P0.05);实验组患者术后20 d外周静脉血中cfDNA总浓度较术前1 d、术后7 d降低, 差异均有统计学意义 (P0.05);实验组患者术后20 d外周静脉血中长片段DNA浓度较术前1 d、术后7 d降低, 差异均有统计学意义 (P0.05) , the total concentration of cfDNA in the peripheral venous blood of the patients in the experimental group was significantly lower than that in the first day of operation and 7 d after operation (P0.05). The long-term DNA concentration in the peripheral venous blood of the experimental group was 20 d after operation. Compared with 1 d before surgery and 7 d after operation, the difference was statistically significant (P<0.05). Conclusion The total concentration of cfDNA and long-segment DNA concentration in peripheral venous blood can indirectly reflect the tumor burden of non-small cell lung cancer patients, and it is expected to be a reference index for auxiliary diagnosis, efficacy evaluation and prognosis of non-small cell lung cancer.
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