PATH-41. PLASMA CELL-FREE DNA (cfDNA) CONCENTRATION IS INDEPENDENTLY ASSOCIATED WITH RADIOGRAPHIC TUMOR BURDEN IN NEWLY DIAGNOSED GLIOBLASTOMA (GBM) PRIOR TO INITIAL SURGICAL RESECTION

摘要

BACKGROUNDDistinguishing between radiographic pseudoprogression and true tumor progression is challenging in patients with GBM. Recent data suggests that plasma cfDNA concentration may serve as a viable surrogate for tumor burden in other malignancies. We performed a pilot study to determine the feasibility of detecting cfDNA in patients with newly diagnosed GBM and explored its correlation with radiographic tumor burden and other relevant clinical variables.