降钙素原检测在新生儿败血症早期诊断中的应用

摘要

目的：探讨血清降钙素原(PCT)作为早期诊断新生儿败血症指标的应用价值。方法应用固相免疫测定法测定84例新生儿血清中降钙素原(PCT),C反应蛋白(CRP)水平,其中败血症组30例、一般感染组28例、非感染组26例。结果败血症组患儿血清PCT、CRP水平显著高于一般感染组和非感染组,差异有统计学意义(P<0.05)；一般感染组与非感染组血清中PCT、CRP水平比较差异有统计学意义(P<0.05)。以0.5ng/mL为临界值,PCT诊断新生儿败血症的敏感度为93.3%,特异度为80.8%；以8.0mg/L为临界值,诊断败血症的敏感度为70.0%,特异度为69.2%。与CRP相比,PCT诊断败血症的敏感性、特异性更高。经抗生素有效治疗后,血清PCT下降幅度明显大于血清CRP下降幅度。结论新生儿血清PCT水平的检测对败血症的早期诊断与疗效评价具有重要价值。%Objective To investigate Procalcitonin (PCT) for early diagnosis of neonatal septicemia. Methods The serum PCT levels were measured with immune chromatography (PCT-Q)assay and compared with the serum C-reactive protein (CRP)in 84 neonates of whom were divided into neonatal septicemia group, common infection group and non-infection group according to discharge diagnosis. Results Serum concentrations of PCT and CRP in neonatal septicemia group were significantly higher than those common group and non-infection group ( <0.05). Serum concentrations of PCT and CRP in neonates with common infection were significantly higher than those non-infection ( < 0.05). Set 0.5ng/ml as cut-of value, PCT was positive in 93.3% neonatal septicemia, the specificity rate was 80.8%. Set 8.0ng/ml as cut-of value, CRP was positive in 70.0%neonatal septicemia, the specificity rate was 69.2%. The sensitivity and specificity rate of PCT were much higher than that of CRP. The level of the serum PCT decreased rapidly during ef ective antibiotic therapy. Conclusion The measurement of PCT wil be very important to the early and dif erential diagnosis and judgment of therapeutic ef icacy of neonatal infection.