73例药物性肝病临床分析

摘要

目的就73例药物性肝病进行临床分析。方法选取我院2010年11月~2013年11月所收治的75例药物性肝病患者进行临床分析。结果29例(39.73%)患者肝损害发生于用药后超过8 w，14例(19.19%)发生于用药后4~8 w，24例(32.88%)发生于用药后1~4 w，6例(8.22%)发生于用药后1 w内。11例（15.07%）的患者嗜酸性粒细胞>6%，65例（89.04%）的患者胆红素异常，68例（93.15%）AST升高，70例（95.89%）ALT升高。本组1例（1.37%）患者死亡，14例(19.18%)转院或者自动出院，58例(79.45%)好转或者治愈。结论药物性肝病的治疗重在预防，尽量不要用对于人体肝脏有毒性的药物，也不能长期大量用药或者滥用药物。%Objective Clinical analysis of 73 cases of drug-induced liver disease. Methods 75 cases of drug-induced liver disease patients in our hospital from 2010 November to 2013 November were carried on clinical analysis. Results 29 cases (39.73%) patients with liver damage occurred in the medication after more than 8 weeks, 14 cases (19.19%) occurred in 4~8 weeks after treatment, 24 cases (32.88%) occurred at 1~4 weeks after treatment, 6 cases (8.22%) occurred at 1 weeks after treatment. In 11 cases (15.07%) were greater than 6%eosinophils, 65 cases (89.04%) of the patients with abnormal bilirubin, 68 cases (93.15%) the elevation of AST, 70 cases (95.89%) increased ALT. The group of 1 patients (1.37%) patients died, 14 cases (19.18%) transferred or discharged, 58 cases (79.45%) improved or cured. Conclusion The treatment of drug-induced liver disease prevention, as far as possible not to use for the human liver toxic drugs, nor a large number of long-term medication or drug abuse.