生物活性玻璃对家兔股骨髁骨缺损的修复实验研究

摘要

Objective:to observe the compatibility and biological repair of a kind bioglass and NovaBone on rabbits femoral condyle bone defect.Methods:64 rabbits are randomly al o-cate to postoperative 4W,8W,12W,24W groups,16 rabbits/group.Each of rabbits was made of models with femoral condyle bone defect,left part is fil ed with Dikang bioglass,and right part with NovaBone as controls,drawing blood at corresponding time point after operations,then having X-ray and observing the pathohistology of femur.Results:After operations,al groups have stable vital signs,regular food and doings,al can stand walk within one week and recover wel;X-rays detect show implant material biodegraded and have obvious osteogenesis,bone devel-oped in the main 12 weeks afteroperation,pasty and massive materials have no dif erence in promoting healing of the bone 24 weeks afteroperation.Conclusions:The bioglass promotes osteogene-sis ef ectively,and shows a good ef ect in bone restoration and has wel biological compatibility.%目的：本动物实验采用家兔股骨髁骨缺损动物模型，观察一种生物活性玻璃及固骼生（NovaBone）对骨凹槽损型伤口的修复作用及生物相容性，该生物材料填充后伤口，终可修复为骨的结构，避免第二次手术。方法：64只家兔随机分为4组，分别为术后4w、8w、12w、24w组，每组16只动物。手术复制股骨髁骨缺损模型，左侧用某公司生物活性玻璃填充骨缺损，右侧用对照品固骼生填充骨缺损，术后取股骨标本进行X线摄片和组织学观察。结果：术后各组动物生命体征平稳，正常进食、活动，1w内所有动物能够站立行走，恢复良好；X线摄片显示术后12 w植入材料降解、新骨生成明显，骨塑形基本完成，术后24 w完全愈合，膏状和块状材料促进骨愈合作用无明显差异。结论：该生物活性玻璃可有效促进新骨生长，具有良好的的骨修复作用，特别对凹槽型伤口具有很好的填充作用；且具有良好的生物相容性。