From the fermentation culture of strain Penicillium sp. MA-37 derived from mangrove rhizosphere, eight compounds were isolated by separation techniques including column chromatography with silica gel and Sephadex LH-20, preparative TLC and re-crystallization. Structures of all purified compounds were elucidated by analysis of their spectroscopic data to be N-(2-methoxy-4-hydroxyphenyl)-malonamic acid (1), N-(2,4-dimethoxyphenyl)-malonamic acid (2), N-(2,4-dimethoxyphenyl)-malonamic acid methyl ester (3), (22E,24R)-ergosta-5,7,22-trien-3β-ol (4), (22E,24R)-Ergosta-4,6,8(14),22-tetraen-3-one (5), (22E,24R)-5α,8α-epidioxyergosta-6,22-dien-3β-ol (6), asperamide B (7), cis-4-hydroxy-6-deoxyscytalone (8). Compound 1 was a new compound, while compounds 2 and 3 were reported as natural products for the first time.% 对采自海南文昌红树林根际土壤样品中分离到的真菌Penicillium sp. MA-37的次生代谢产物的化学成分进行了研究.利用硅胶柱层析、葡聚糖凝胶Sephadex LH-20柱层析、制备薄层层析以及重结晶等分离方法并通过现代波谱技术共分离、鉴定了8个天然产物,分别为：氮-(2-甲氧基-4-羟基苯)-丙酰胺酸(1),氮-(2,4-二甲氧基苯)-丙酰胺酸(2),氮-(2,4-二甲氧基苯)-丙酰胺酸甲酯(3),(22E,24R)-麦角甾-5,7,22-三烯-3β-醇(4),(22E,24R)-麦角甾-4,6,8(14),22-四烯-3-酮(5),(22E,24R)-5α,8α-环二氧麦角甾-6,22-双烯-3β-醇(6), asperamide B (7), cis-4-hydroxy-6-deoxyscytalone (8)；其中化合物1为新化合物,化合物2和3为新天然产物.
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